Publications – FOR-2800

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Project-related publications of the FOR2800 from the first funding period

(collaboration papers and manuscripts in bold, FOR2800 PIs underlined)

SP1, Petra Beli:

Mosler, T., Conte, F., Mikicic, I., Kreim, N., Möckel, M., Flach, J., Luke, B. & Beli, P. R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability. Nature Commun., in press. doi: 10.21203/rs.3.rs-337351/v1. (2021).

Roeschert, I., Poon, E., Henssen, A. G., Garcia, H. D., Gatti, M., Giansanti, C., Jamin, Y., Ade, C. P., Gallant, P., Schülein-Völk, C., Beli, P., Richards, M., Rosenfeldt, M., Altmeyer, M., Anderson, J., Eggert, A., Dobbelstein, M., Bayliss, R., Chesler, L., Büchel, G., … & Eilers, M. Combined inhibition of Aurora-A and ATR kinase results in regression of MYCN-amplified neuroblastoma. Nature Cancer 2, 312–326 (2021).

SP2, Holger Bastians:

Schmidt, A.K.*, Böhly, N.*, Zhang, X.*, Slusarenko, B.O., Hennecke, M., Kschischo, M. and H. Bastians. 2021. Dormant replication origin firing links replication stress to whole chromosomal instability in human cancer. Cell Rep. 2022 Dec 13;41(11):111836. doi: 10.1016/j.celrep.2022.111836

Schmidt, A.K., Pudelko, K., Boekenkamp, J.E., Berger, K., Kschischo, M. & Bastians H. The p53/p73 – p21^CIP1 tumor suppressor axis guards against chromosomal instability by restraining CDK1 in human cancer cells. Oncogene 40, 436-451 (2021).

Böhly, N., Kistner (Hennecke), M. & Bastians, H. Mild replication stress causes aneuploidy by deregulating microtubule dynamics in mitosis. Cell Cycle 18, 2770-2783 (2019).

SP3, Maik Kschischo:

Zhang, X. & Kschischo, M. Distinct and common features of numerical and structural chromosomal instability across different cancer types. bioRxiv, doi.org/10.1101/2021.10.15.464567 (2021a).

Zhang, X. & Kschischo, M. MFmap: A semi-supervised generative model matching cell lines to tumours and cancer subtypes. bioRxiv, doi.org/10.1101/2021.07.15.452446 (2021b).

Schmidt, A.K.*, Böhly, N.*, Zhang, X.*, Slusarenko, B.O., Hennecke, M., Kschischo, M. and H. Bastians. 2021. Dormant replication origin firing links replication stress to whole chromosomal instability in human cancer. Cell Rep. 2022 Dec 13;41(11):111836. doi: 10.1016/j.celrep.2022.111836

Chunduri, N.K., Menges, P., Zhang, X., Wieland, A., Gotsmann, V.L., Mardin, B.R., Buccitelli, C., Korbel, J.O., Willmund, F., Kschischo, M., Räschle, M. & Storchova, Z. Systems approaches identify the consequences of monosomy in somatic human cells. Nature Communications 12, 5576. (2021).

Seget, K., Bernhard, S.V., Kuffer, C., Keuper, K., Boekenkamp, J., Krastev, D., Theis, M., Räschle, M., Kschischo, M., Buchholz, F. & Storchova, Z. Genome-wide screen identifies USP28 and SPINT2 as factors mediating the cell cycle arrest after whole genome doubling. bioRxiv, doi.org/10.1101/2020.09.18.303834 (2020).

SP4, Matthias Dobbelstein:

Tayeh, Z., Stegmann, K., Kleeberg, A., Friedrich, M., Choo, J.A., Wollnik, B. & Dobbelstein, M. Centrosome impairment causes DNA replication stress through MLK3/MK2 signaling and R-loop formation. bioRxiv, doi.org/10.1101/2020.01.09.898684 (2020).

SP5, Bernd Wollnik:

Gönenc, I., Wolff, A., Schmidt, J., Zibat, A., Shomroni, O., Salinas, G., Müller, C., Cyganek, L., Argyriou, L., Räschle, M., Yigit, G. & Wollnik, B. Single-cell transcription profiles in Bloom syndrome patients link BLM deficiency with altered condensin complex expression signatures. Human Molecular Genetics, in press. doi: 10.1093/hmg/ddab373

Schmidt, J., Goergens, J., Pochechueva, T., Kotter, A., Schwenzer, N., Sitte, M., Werner, G., Altmüller, J., Thiele, H., Nürnberg, P., Isensee, J., Li, Y., Müller, C., Leube, B., Reinhardt, H.C., Hucho, T., Salinas, G., Helm, M., Jachimowicz, R., Wieczorek, D., Kohl, T., Lehnart, S., Yigit, G. & Wollnik, B. Biallelic variants in YRDC cause a developmental disorder with progeroid features. Hum Genet, in press. doi: 10.1007/s00439-021-02347-3. (2021).

Shomroni, O., Sitte, M., Schmidt, J., Parbin, S., Ludewig, F., Yigit, G., Zelarayan, L.C., Streckfuss-Bömeke, K., Wollnik, B. & Salinas, G. A novel single-cell RNA-sequencing platform and its applicability connecting genotype to phenotype in ageing-disease. bioRxiv, doi.org/10.1101/2021.10.25.465702 (2021).

SP6, Markus Räschle:

Larsen, N.B., Gao, A.O., Sparks, J.L., Gallina, I., Wu, R.A., Mann, M., Räschle, M., Walter, J.C., Duxin JP. Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts. Mol Cell 73, 574-588 (2019).

SP7, Johanna Flach (FOR2800 PI until 2020):

Mosler, T., Conte, F., Mikicic, I., Kreim, N., Möckel, M., Flach, J., Luke, B. & Beli, P., R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability. Nature Commun., under revision. doi: 10.21203/rs.3.rs-337351/v1 (2021).

Flach, J., Jann, J.C., Knaflic, A., Riabov, V., Streuer, A., Altrock, E., Xu, Q., Schmitt, N., Obländer, J., Nowak, V., Danner, J., Mehralivand, A., Hofmann, F., Palme, I., Jawhar, A., Wuchter, P., Metzgeroth, G., Nolte, F., Hofmann, W.K. & Nowak, D. Replication stress signaling is a therapeutic target in Myelodysplastic Syndromes with splicing actor mutations. Haematologica 105, doi:10.3324/haematol.2020.254193 (2020).

SP8, Zuzana Storchova:

Gemble, S., Bernhard S,V., Srivastava, N., Wardenaar, R., Nano, M., Macé, A., Tijhuis, A.E., Keuper, K., Spierings, D.C.J., Hochegger, H., Piel, M., Foijer, F., Storchová, Z. & Basto, R. Mechanisms of genetic instability in a single S-phase following whole genome doubling, bioRxiv doi.org/10.1101/2021.07.16.452672. (2021).

Kneissig, M., Keuper, K., de Pagter, M.S., van Roosmalen, M.J., Martin, J., Otto, H., Passerini, V., Campos Sparr, A., Renkens, I., Kropveld, F., Vasudevan, A., Sheltzer, J.M., Kloosterman, W.P. & Storchova, Z. Micronuclei-based model system reveals functional consequences of chromothripsis in human cells. Elife 8, e50292 (2019).

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